HIPERGLIKEMIA PADA ANAK DENGAN DIAGNOSIS DIABETES MELLITUS TYPE-1 , DIFERENTIAL DIAGNOSTIC MATURITY ONSET DIABETES OF THE YOUNG (MODY)

Diagnosis and management of maturity onset diabetes of the young (MODY).

[Diabetes mellitus onset in young patient: type 1 diabetes?].

mptomatic diabetes as a manifestation of another underng condition is uncommon, and usually due to the use drugs with hyperglycemic potential or to neoplastic prosses in the pancreatic area. Among drugs, special mention uld be made of high-dose steroids and, more recently d in young patients, atypical neuroleptics.1 The onset of rdinal symptoms of diabetes mellitus (DM) in a patient der 40 year...

[Mature onset diabetes of the young (MODY)].

Maturity-onset diabetes of the young (MODY) is a rare form of juvenile diabetes mellitus, defined by early onset, absence of ketosis, non-insulin-dependent diabetes and autosomal dominant inheritance. Advances in molecular genetic analysis have identified mutations accounting for different MODY subtypes, all of them associated with defects of insulin secretion. We present a case of a nine year-...

Environmental Factors before the Onset of Type 1 Diabetes Mellitus: A Case-Control Study

Objective: The role of environmental factors in the development of type1 diabetes mellitus (T1D) is inconclusive. This study aimed to investigate the associations between selected environmental factors and T1D. Materials and Methods: This group matched case-control study included diabetic and healthy subjects younger than 19 years old in 2017. Cases were diabetic subjects diagnosed before the ...

The type and the position of HNF1A mutation modulate age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY)-3.

OBJECTIVE The clinical expression of maturity-onset diabetes of the young (MODY)-3 is highly variable. This may be due to environmental and/or genetic factors, including molecular characteristics of the hepatocyte nuclear factor 1-alpha (HNF1A) gene mutation. RESEARCH DESIGN AND METHODS We analyzed the mutations identified in 356 unrelated MODY3 patients, including 118 novel mutations, and se...